| Issue |
E3S Web Conf.
Volume 53, 2018
2018 3rd International Conference on Advances in Energy and Environment Research (ICAEER 2018)
|
|
|---|---|---|
| Article Number | 01046 | |
| Number of page(s) | 5 | |
| Section | Energy Engineering, Materials and Technology | |
| DOI | https://doi.org/10.1051/e3sconf/20185301046 | |
| Published online | 14 September 2018 | |
Spectrophotometric Determination of Methimazole by Silicomolybdenum Blue
College of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015, P. R. China
* Corresponding author: awxrong5093@sohu.com, btcq@jyu.edu.cn
Under optimum reaction conditions, Ammonium silicomolybdate could be quantitatively reduced to silicomolybdenum blue by hydrosulfuryl(-SH) in methimazole molecule, and the content of methimazole was determinated indirectly through determinating the absorbance of the silicomolybdenum blue. A novel method for the spectrophotometric determination of methimazole by silicomolybdenum blue has been established. The results showed that the maximum absorption wavelength of silicomolybdenum blue is 730 nm, good linear relationship is obtained between the absorbance of silicomolybdenum blue and the concentration of methimazole in the range of 8.000-160.0μg/mL, and the equation of the linear regression is A=0.0757+11.547ρ (mg/mL) with a linear correlation coefficient is 0.9998. This proposed method has been applied to determinate of methimazole in tablets, and the results agree well with those obtained by pharmacopoeial method.
© The Authors, published by EDP Sciences, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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