Issue |
E3S Web Conf.
Volume 185, 2020
2020 International Conference on Energy, Environment and Bioengineering (ICEEB 2020)
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|
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Article Number | 03034 | |
Number of page(s) | 3 | |
Section | Medical Biology and Medical Signal Processing | |
DOI | https://doi.org/10.1051/e3sconf/202018503034 | |
Published online | 01 September 2020 |
Variation in Spontaneous Activity and Visual Evoked Response in Primary Visual Cortex of the S334ter-3 Rats
1 The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, University of Electronic Science and Technology of China, Chengdu 610054, People's Republic of China
2 Department of Electrical Engineering, City University of Hong Kong, Tat Chee Avenue, Hong Kong SAR, China
3 Centre for Biosystems, Neuroscience, and Nanotechnology, City University of Hong Kong, Tat Chee Avenue, Hong Kong SAR, China
S334ter-3 retinal degeneration (RD) rats have been widely used to investigate degenerative diseases of the retina. In this model, morphological and electrophysiological changes have been observed in the retina, superior colliculus and primary visual cortex (V1). In this study, experimental rats (S334ter-3) carried one copy of the mutant transgene. We measured the extracellular responses in the primary visual cortex to three stimulus contrast levels (spontaneous activity, medium contrast, and high contrast) at the preferred parameters of each recorded cell under classical receptive field (CRF) stimulation. Then we compared the responses (spontaneous activity and the visual evoked responses) in RD rats with those in wildtype rats. Our results show that V1 cells in the RD group exhibit stronger spontaneous activity but weaker stimulus-evoked responses at medium and high contrasts. At the same time, compared with WT group, RD group also showed a narrow dynamic range. These results indicate the decrease in discriminating the stimuli contrast and loss in responses and lower signal to noise ratio after retina degeneration.
© The Authors, published by EDP Sciences, 2020
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