Issue |
E3S Web Conf.
Volume 218, 2020
2020 International Symposium on Energy, Environmental Science and Engineering (ISEESE 2020)
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Article Number | 03052 | |
Number of page(s) | 7 | |
Section | Environmental Chemistry and Environmental Pollution Analysis and Control | |
DOI | https://doi.org/10.1051/e3sconf/202021803052 | |
Published online | 11 December 2020 |
Gene Expression Profile of RNA N1-methyladenosine methyltransferases
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin China
* Corresponding author: Jianyu.Zhang@tju.edu.cn, rmzwork@163.com
N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of methyltransferases like domains and conserved S-adenosylmethionine (SAM) binding domains formed by the central sevenstranded beta-sheet structure. However, comprehensive analysis of the gene expression profile of such enzymes has not been performed to classify them according to evolutionary criteria and to guide the functional prediction. Here, we conducted extensive searches of databases to collect all members of previously identified m1A RNA methyltransferases. And we report bioinformatics studies on gene expression profile based on evolutionary analysis, sequence alignment, expression in tissues and cells within the family of RNA methyltransferases. Our analysis showed that the base modification behavior mediated by m1A RNA methyltransferases evolved from invertebrate, and the active sites of m1A RNA methyltransferases were highly conserved during the evolution from invertebrates to human. And m1A RNA methyltransferases have low tissue and cell specificity.
© The Authors, published by EDP Sciences, 2020
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