| Issue |
E3S Web Conf.
Volume 300, 2021
2021 2nd International Conference on Energy, Power and Environmental System Engineering (ICEPESE2021)
|
|
|---|---|---|
| Article Number | 01023 | |
| Number of page(s) | 5 | |
| Section | Energy and Power Engineering | |
| DOI | https://doi.org/10.1051/e3sconf/202130001023 | |
| Published online | 06 August 2021 | |
Study on the fluorescence properties of the interaction between felodipine and bovine serum protein
1
College of Pharmacy, Jiamusi University, Jiamusi, China
2
School of materials science and Engineering, Jiamusi University, Jiamusi, China
* Corresponding author: yuguanglv@163.com
The interaction between felodipine and bovine serum protein was studied, the optimal experimental conditions were selected, and the fluorescence quenching mechanism was discussed. The interaction between filodipine and bovine serum protein was determined by UV spectrophotometry, and the optimal experimental conditions were selected by control variable method. The mechanism of fluorescence quenching in the system was explored by fluorescence spectrophotometry. The fluorescence intensity of the system between felodipine and bovine serum protein was the most obvious under the experimental conditions of buffer solution pH 7.4, felodipine concentration 8.0*10-4mol/L, reaction time 30min and 25°C. Static fluorescence quenching caused by the formation of complex compounds.
Key words: Bovineserumprotein / Felodipine / Complex / Fluorescence properties study
© The Authors, published by EDP Sciences, 2021
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