Effect of probiotics Zoonorm and Subalin on the immunophysiological system and microbiocenosis of carp

¹ All-Russian Scientific Research Institute of Fisheries and Oceanography (VNIRO), Dmitrov district, Moscow region, 141821, Russia
² Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K.I. Skryabin, Moscow, 109472, Russia
³ Don State Technical University, Rostov-on-Don, 344003, Russia

^* Corresponding author: regiotf@yandex.ru

Abstract

Aquaculture is a fast-growing sector in Russia. To grow fish to a greater extent than for other agricultural objects, it is necessary to preserve and maintain natural habitat conditions. Minor changes in the aquatic environment, such as changes in pH, temperature fluctuations, and the presence of organic pollutants can lead to a decrease in the number of fish. Use of antibiotic drugs for the prevention and treatment of diseases in fish farming can lead to a change in the microbiocenosis of fish and the hydroecosystem, the appearance of antibiotic-resistant strains of pathogenic microorganisms and a change in the immunophysiological status of the fish organism. To date, a promising and effective therapeutic and prophylactic agent in fish farming is the use of probiotics, which have pronounced antimicrobial activity against pathogenic and conditionally pathogenic microorganisms, immunocorrecting and anti-inflammatory effect. As a result of our research, we have established the effectiveness of the use of preparations Subalin containing Bacillus subtilis and Zoonorm containing live bacteria Bifidobacterium bifidum in the cultivation of carp. A positive effect on the increase in body weight of fish was revealed, the level of contamination of parenchymal organs of fish with bacterial flora decreased, specific and nonspecific resistance increased.