| Issue |
E3S Web of Conf.
Volume 381, 2023
International Scientific and Practical Conference “Development and Modern Problems of Aquaculture” (AQUACULTURE 2022)
|
|
|---|---|---|
| Article Number | 01098 | |
| Number of page(s) | 8 | |
| Section | Agriculture, River Ecosystems and Environment | |
| DOI | https://doi.org/10.1051/e3sconf/202338101098 | |
| Published online | 14 April 2023 | |
Genetic characteristics of the course of chronic hepatitis
Tashkent medical academy, 2nd Shifokorlar street, 2, 100109, Tashkent, Uzbekistan
* Corresponding author: article_01@mail.ru
The aim of the study was a comparative analysis of genotypic variants of TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the effect of TNF-α gene genotypes on the course of the disease indicates an increased risk of CVHC development with both moderate and highly active course of the disease in carriers of the G / A + A / A genotype combination. The data obtained allow us to conclude that the carriage of the “G” allele and the combination of genotypes A / G + G / G of the –A49G polymorphism of the CTLA-4 gene are associated not only with a decrease in the risk of CVHC development, but also with a lower intensity of inflammation and fibro-formation in the liver and a high probability of favorable course of the disease.
© The Authors, published by EDP Sciences, 2023
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