| Issue |
E3S Web Conf.
Volume 383, 2023
International Scientific Conference Transport Technologies in the 21st Century (TT21C-2023) “Actual Problems of Decarbonization of Transport and Power Engineering: Ways of Their Innovative Solution”
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|---|---|---|
| Article Number | 04043 | |
| Number of page(s) | 8 | |
| Section | Mechanical Engineering and New Energy Technologies | |
| DOI | https://doi.org/10.1051/e3sconf/202338304043 | |
| Published online | 24 April 2023 | |
Mathematical modelling of regulatory mechanisms of cell groups functioning at norm and at unregulated cell division
1
Research Institute for the Development of Digital Technologies and Artificial Intelligence, 17A, Boz-2, 100125 Tashkent, Uzbekistan
2
Tashkent State Pedagogical University, Bunyodkor avenue, 27, 100070 Tashkent, Uzbekistan
3
Fiscal institute Under the State Tax Committee of the Republic of Uzbekistan, Str. Kichik Halka Yuli (Malaya koltsevaya), 3, 100173 Tashkent, Uzbekistan
4
National Research University TIIAME, st. Kori Niyazov, house 39, 100000 Tashkent, Uzbekistan
* Corresponding author: mhidirova@yandex.ru
This paper presents a method for modeling organs and tissues based on the equations of the functional unit of organs and tissues (FUOT) and mathematical models for the main cellular functions: division, growth, differentiation, performance of specific functions, aging, apoptosis and natural death. The elements of FUOT are cells. The analysis shows that there are short circuits of regulation, which in specific realizations of cell development correspond to stable or partially stable cellular structures. This can occur as a normal phenomenon in the form of an adaptive response to stressful influences, and as an abnormal pathological condition. Such partial FUOT can be called minifuot. The study of the proliferative minifuot equations show the presence of a nonzero stable equilibrium position, and a stable limit cycle in the first quadrant. The results of these studies can be useful in studying the mechanisms of cell groups functioning at norm and at unregulated cell division.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).
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