| Issue |
E3S Web Conf.
Volume 385, 2023
2023 8th International Symposium on Energy Science and Chemical Engineering (ISESCE 2023)
|
|
|---|---|---|
| Article Number | 04008 | |
| Number of page(s) | 8 | |
| Section | Polymer Chemistry and Chemical Research Progress | |
| DOI | https://doi.org/10.1051/e3sconf/202338504008 | |
| Published online | 04 May 2023 | |
Introduction to Retrosynthesis: Strategies and Approaches
1 St. John’s School, Vancouver, BC V6K 2J1, Canada
2 Hongwen School Qingdao Campus, Qingdao, 266100, China
* Corresponding author. Email: Wanghaochen0519@gmail.com
Chemical synthesis is a powerful tool for human being as it provides many useful products, especially those that do not exist or only exist in a small quantity in nature. Since it is often hard to design and visualize the reactions of organic synthesis, retrosynthesis is often used to achieve a desired product. This review is an introduction of the concepts of retrosynthetic analysis and how it can be established, including the basic steps and strategies. It also discuss the guiding principles of retrosynthesis (simplification, complexity, yield) along with some possible problems and coping strategies in the analyses, including functional group disconnections, fine tuning, and illogical disconnections.
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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