| Issue |
E3S Web of Conf.
Volume 389, 2023
Ural Environmental Science Forum “Sustainable Development of Industrial Region” (UESF-2023)
|
|
|---|---|---|
| Article Number | 03108 | |
| Number of page(s) | 8 | |
| Section | Precision Agriculture Technologies for Crop and Livestock Production | |
| DOI | https://doi.org/10.1051/e3sconf/202338903108 | |
| Published online | 31 May 2023 | |
CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis
Department of Biology, Faculty of Science, University of Kufa, Kufa, Iraq.
* Corresponding author: ahmedaj.aljanabi@uokufa.edu.iq
Tuberculosis (TB) is a serious lung infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis) is highly contagious, and can be spread through the air from an infected person to others. The aim of this article was to evaluate the immunological role of CD4 and CD20 in patients infected with M. tuberculosis and multi-drug resistant tuberculosis (MDRTB). A total of 182 individuals suspected with M. tuberculosis admitted to the tuberculosis center in AL-Najaf City, Iraq. A sputum acid-fast stain was performed for each individual and GeneXpert® heminested real time PCR has been performed for MDR-M. tuberculosis detection. CD4 and CD20 have been measurement in serum of infected individual using ELISA technique. Serum CD4 and CD20 levels were significantly elevated (P<0.05) in patients with M. tuberculosis and MDR-M. tuberculosis groups as compared with control subjects. The MDRTB group showed higher serum CD4 and CD20 levels (P<0.05) than the M. tuberculosis group. This study showed that CD4 and CD20 had a relationship with M. tuberculosis and might be used to help diagnose TB.
Key words: CD4 / CD20 / TB / MTB / MDRMTB / GeneXpert
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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