| Issue |
E3S Web of Conf.
Volume 389, 2023
Ural Environmental Science Forum “Sustainable Development of Industrial Region” (UESF-2023)
|
|
|---|---|---|
| Article Number | 03109 | |
| Number of page(s) | 10 | |
| Section | Precision Agriculture Technologies for Crop and Livestock Production | |
| DOI | https://doi.org/10.1051/e3sconf/202338903109 | |
| Published online | 31 May 2023 | |
Interleukin 18 and interleukin 22 as important immune markers in patients with tuberculosis
Department of Microbiology, Faculty of Science, University of Kufa, Kufa, Iraq
* Corresponding author: ahmedaj.aljanabi@uokufa.edu.iq
Tuberculosis (TB) is a lung infection caused by the bacterium Mycobacterium tuberculosis (MTB). TB is a leading cause of death globally, accounting for approximately 1.5 million deaths per year. The aim of this article was to evaluate the immunological role of Interleukin (IL) 18 and Interleukin 22 in patients infected with MTB and multi-drug resistant tuberculosis MDRTB. A total of 182 individuals suspected with MTB admitted to the tuberculosis center in AL-Najaf City, Iraq. A sputum acid-fast stain was performed for each individual and GeneXpert® heminested real time PCR has been performed for MDRTB detection. The two Interleukins was measurement in serum of infected individual using ELISA technique. Out of 182 individuals, there were 20 infected with MTB and 15 infected with MDRTB. Serum IL18 and IL22 levels were significantly elevated (P<0.05) in patients with MTB and MDRTB groups as compared with control subjects. The MDRTB group showed higher serum IL18 and IL22 levels (P<0.05) than the MTB group. This study showed that IL18 and IL22 had a relationship with MTB and might be used to help diagnose TB; Clinical diagnosis of TB may be aided by these tests.
Key words: IL18 / IL22 / TB / MTB / MDRMTB / GeneXpert
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.