Association of circadian rhythm disruption with metabolic diseases represented by obesity

Department of Biological Science, University of Bristol, Bristol, BS8 1QU, UK

^* Corresponding author: id22287@bristol.ac.uk

Abstract

The majority of creatures on Earth possess an intrinsic biological clock which situates in the suprachiasmatic nucleus of the hypothalamus. It produces a circadian rhythm that coincides with the Earth’s 24-hour cycle through a feedback loop that involves both transcription and translation, which means in regulating metabolism and energy homeostasis of various peripheral organs, such as liver, it plays an vital part. As a result, it has an intricate association in maintaining metabolic health. Outer environmental factors like lifestyle changes may cause Circadian rhythm disorders, and causing higher risk of obesity and metabolic diseases. Moreover, the intricate relationship between circadian rhythms and lipid metabolism is intricately linked to the progression of obesity. The disruption of these processes can significantly heighten the susceptibility to obesity through several mechanisms, therefore intensifying circadian abnormalities and establishing a detrimental cycle. This review will study the correlation between circadian rhythm and obesity, exploring many aspects such as process, influence and various factors.