Issue |
E3S Web of Conf.
Volume 553, 2024
2024 International Conference on Ecological Protection and Environmental Chemistry (EPEC 2024)
|
|
---|---|---|
Article Number | 05025 | |
Number of page(s) | 6 | |
Section | Medical Treatments and Therapies | |
DOI | https://doi.org/10.1051/e3sconf/202455305025 | |
Published online | 24 July 2024 |
The effects of PIK3CA mutations on cervical cancer
School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510000, China
* Corresponding author: 2100930458@gdpu.edu.cn
Cervical cancer is one of the major problems affecting women’s health worldwide. Dysregulation of cellular signalling pathways, PI3K-Akt axis, in particular, may be linked to the development and malignant metastasis of cervical cancer. PIK3CA gene codes a catalytic subgroup of phosphatidylinositol 3-Kinase A (PI3K-A), which is an essential element in PI3K-Akt pathway. However, the particular function of the PI3K-Akt axis in cervical cancer remains unclear. Mutations of PIK3CA in cervical cancer may be correlated with disease progression. Mutant PIK3CA may activate PI3K-AKT-mTOR and PIK3CA-E545K-SIRT4 signalling pathways, which in turn promotes cell propagation, invasion, and metastasis. Thus, the potential therapeutic approaches for targeting PIK3CA to treat cervical cancer have been studied, including several commercial inhibitors such as Buparlisib, Alpelisib, Dactolisib, etc. This review outlines the function of mutant PIK3CA and places special emphasis on the potential for targeting the PI3K-Akt axis as well as the effectiveness of PIK3CA inhibition as a treatment for cervical cancer. Clarification of the mechanism and clinical relevance of PIK3CA mutation-induced cervical cancer is still needed.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.