A Study of Some Biochemistry Parameters in Blood Serum of Patients with Chronic Renal Failure

¹ Department of Chemistry, College of Education for Pure Science, University of Tikrit, Tikrit, 34001 Iraq
² Clinical Biochemistry, Dentistry college, University of Tikrit, Tikrit, 34001 Iraq

Abstract

In chronic renal failure, the kidneys stop removing wastes and ions from the blood. As a result of this disease, an imbalance occurs in the concentration of PTH and Vitamin D3, and the concentration of urea and creatine increases, which suffer from the kidneys’ inability to excrete them from the body with urine. As for calcium and phosphorus, they are affected by the concentration of each. Of PTH and Vitamin D3. This cross-sectional study included 60 patients with the Chronic renal failure (the first group) and 60 healthy volunteers (the control group). The ELISA approach was utilized to ascertain the serum levels of PTH and Vitamin D3) while Spectrophotometer was utilized to ascertain the serum levels of urea , creatinine , calcium and phosphor ion. Serum levels of PTH , Phosphor ions, urea and creatinine were significantly higher in the Chronic renal failure group (310.752±53.888) , (4.758±1.305),( 113.467±18.446 ) and (6.311±1.366 ) than in the control group (44.608±8.673) , (3.534±0.687),(36.085±4.887 ) and (0.982±0.213 ) respectively, with a p-value of less than 0.001 while Serum levels of Vitamin D3 and Calcium ions were significantly lower in the Chronic renal failure group (13.126±2.596) and (8.480±0.6273) than in the control group (51.100±10.146) , and (9.405±0.6550) respectively, with a p-value of less than 0.001.