| Issue |
E3S Web Conf.
Volume 210, 2020
Innovative Technologies in Science and Education (ITSE-2020)
|
|
|---|---|---|
| Article Number | 06017 | |
| Number of page(s) | 12 | |
| Section | Livestock and Veterinary | |
| DOI | https://doi.org/10.1051/e3sconf/202021006017 | |
| Published online | 04 December 2020 | |
Immunobiotics mechanisms of action and prospects of use in veterinary medicine
1 Academy of Biology and Biotechnology of Southern Federal University, 344090, Stachki avenue, 194 building 1, Rostov-on-Don, Rostov obl., Russia
2 Don State Technical University, 344003, Gagarin sq., 1, Rostov-on-Don, Russia
* Corresponding author: acalexdc99@gmail.com
Probiotics are becoming more and more common means of combating intestinal diseases of various origins: infectious pathologies, chronic inflammation, autoimmune disorders. The complex action, coupled with low side effects, makes probiotics promising drugs, especially in veterinary medicine, with an increasing trend towards the inefficient use of antibiotics in the livestock industry. One of the main mechanisms of probiotics action - modulation of host immunity - is perhaps the most difficult and, at the same time, the most actively studied since it is crucial for therapy. Immunobiotics (probiotics that modulate the host's immune response) interact with various innate and adaptive immune cells, changing the expression of pro- and anti-inflammatory cytokines. This action is provided by both the cellular components of probiotic microorganisms and their metabolites and is primarily associated with the host's immunocompetent cells' pattern-recognition receptors, although other molecular mechanisms also exist. This review aims to briefly describe both the molecular mechanisms of immunomodulation by probiotics and the prospects for their use in veterinary medicine.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.