| Issue |
E3S Web Conf.
Volume 254, 2021
International Scientific and Practical Conference “Fundamental and Applied Research in Biology and Agriculture: Current Issues, Achievements and Innovations” (FARBA 2021)
|
|
|---|---|---|
| Article Number | 09011 | |
| Number of page(s) | 7 | |
| Section | Actual Problems of Veterinary Medicine | |
| DOI | https://doi.org/10.1051/e3sconf/202125409011 | |
| Published online | 05 May 2021 | |
Toxic action of substances from male fern Dryopteris filix-mas (L.) Schott (1834) on free-living soil nematode Caenorhabditis elegans Maupas (1900)
1 Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, 420087 Kazan, Russian Federation
2 Federal State Budgetary Institution of Science, Federal Research Center, Kazan Scientific Center of Russian Academy of Sciences, 420111 Kazan, Russian Federation
* Corresponding author: tbkalinnikova@gmail.com
The study of biological activity of extracts from roots and rhizomes of male fern Dryopteris filix-mas was carried out in experiments with soil nematode Caenorhabditis elegans. The toxicity of extracts of D. filix-mas roots and rhizomes obtained by different methods varied over a wide range. Crude extract of male fern roots and rhizomes in concentration range 62.5–250 µg/ml had a weak toxic action on C. elegans organism by inducing death of 26.0–43.3% nematodes. The toxicity of relatively high concentrations (500 and 250 µg/ml) of water-ethanolic extracts might be compared with such of crude extract in concentrations 62.5–250 µg/ml. Biological activity of filicinic acids ethers was found very high: concentrations of crude extract of D. filix-mas roots and rhizomes and concentrations of filicinic acids ethers with similar toxicity for C. elegans organism were 40-fold different. Substances isolated from D. filix-mas roots and rhizomes have nematicidal activity and may be used for development of drugs to treat helminthiasis of humans and animals.
© The Authors, published by EDP Sciences, 2021
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