E3S Web Conf.
Volume 176, 2020International Scientific and Practical Conference “From Inertia to Develop: Research and Innovation Support to Agriculture” (IDSISA 2020)
|Number of page(s)||7|
|Section||Actual Problems of Veterinary Medicine|
|Published online||22 June 2020|
Soil nematode Caenorhabditis elegans Maupas as a convenient model organism to study anthelmintic activity of plant extracts
1 Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences, 420054, Daurskaya str., 28, Kazan, Russian Federation
2 Kazan (Volga region) Federal University, 420008, Kremlevskaya str., Kazan, Russian Federation
* Corresponding author email@example.com
The article deals with the study of the possibility to use free-living soil nematode C. elegans in researches of anthelmintic activity of plant raw material. A. sativum juice and aqueous extract of T. vulgare flowers were used in experiments. It is shown that both A. sativum juice and tansy flowers extract caused dose-dependent disturbances of C. elegans swimming motor program. These disturbances are similar with disturbances caused by agonist of cholinoreceptors levamisole. Therefore, the target of A. sativum juice and T. vulgare extract action is C. elegans cholinergic system. The mechanism of toxic action of A. sativum and T. vulgare on C. elegans organism consists in hyperactivation of nicotinic cholinoreceptors. The possibility of quick adaptation of C. elegans nicotinic cholinoreceptors to active components of tansy flowers extract was revealed. Soil nematode C. elegans may be used for investigation of anthelmintic activity of A. sativum and T. vulgare for the purpose of identification of secondary metabolites responsible for the toxic action on helminths.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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