Statistical Investigation of Correlation between Cardiovascular Event ad Hypertension

¹ School of China Medical University, Shenyang, Province Liaoning ( 110122), China ;
² University of British Columbia, British Columbia, Vancouver ( V6T 1Z4), Canada ;
³ School of Nanjing Medical University, Nanjing, Province Jiangsu ( 210000), China ;

^† These authors contributed equally.
^* Corresponding author:
^a Idai02@qub.ac.uk,
^b SChristina0214@gmail.com
^c zdn011027@163.com

Abstract

Cardiovascular disease is one of the most severe health killers in modern life. In this study, the association among the risk of cardiovascular diseases, patients’ blood pressure and treatment was analyzed. This study makes a secondary analysis on the data from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) database. Participants have recruited 39705 representative participants with diverse blood pressure. The results show that the treated participants have a higher proportion of diabetes mellitus, dyslipidemia, and history of cardiovascular diseases (P<0.0001), compared with untreated participants. During the 10-year follow-up period, there were 2032 cardiovascular deaths distributed among coronary heart disease(CHD), heart failure, and stroke. The treated participants showed an significantly risk for cardiovascular mortality (Hazard ratios (HR):1.5; 95% confidence intervals (CI):1.36-1.66), CHD (HR:1.53, 95%CI: 1.23-1.9), heart failure (HR:1.39; 95%CI: 1.09-1.76) and stroke (HR:1.48; 95%CI: 1.28-1.72). Especially for the participants under antihypertensive medication, their risk of cardiovascular mortality was 1.5 times higher than that of the untreated participants.