| Issue |
E3S Web Conf.
Volume 391, 2023
4th International Conference on Design and Manufacturing Aspects for Sustainable Energy (ICMED-ICMPC 2023)
|
|
|---|---|---|
| Article Number | 01133 | |
| Number of page(s) | 17 | |
| DOI | https://doi.org/10.1051/e3sconf/202339101133 | |
| Published online | 05 June 2023 | |
Role of Exosomes in Tumor Development: Current Knowledge and Future Directions
Department of Medical Laboratory Technique, AlNoor University College, Nineveh, Iraq
* Corresponding Author: amina.jassem@alnoor.edu.iq
The role of exosomes and how they act at the tumour site are subjects of growing study. These macrovesicles can be formed by a variety of cell types, including immunological and mesenchymal stem cells (MSCs). In particular, exosome synthesis by tumor cells is crucial because these exosomes can be transported by blood to distant organs and enhance the probability of tumor spread. Exosomes may have tumor-inhibiting effects depending on the kind of tumor and cell source, despite data indicating that they have tumor-promoting qualities. This review seeks to provide a thorough evaluation of exosome biogenesis, composition, and isolation before highlighting current understanding of their function in promoting or inhibiting cancer by paying particular attention to exosomes produced by MSCs (MSC-EXOs).
Key words: Composition / Biogenesis / Exosomes / Tumor development / Mesenchymal stem cells (MSCs) / Immune cells / Macrovesicles / Tumor spread / Tumor-inhibiting effects / Tumor-promoting qualities / Cancer / Isolation / MSC-EXOs
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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