| Issue |
E3S Web of Conf.
Volume 488, 2024
1st International Conference on Advanced Materials & Sustainable Energy Technologies (AMSET2023)
|
|
|---|---|---|
| Article Number | 03022 | |
| Number of page(s) | 7 | |
| Section | Green Buildings; Carbon Capture & Recycling of Energy Materials | |
| DOI | https://doi.org/10.1051/e3sconf/202448803022 | |
| Published online | 06 February 2024 | |
Cytotoxicity of synthesized silver nanoparticles on breast cancer cells
1 Department of Biological Science, School of Medical and Life Sciences, Sunway University, 47500 Petaling Jaya, Malaysia
2 Department of Medical Science, School of Medical and Life Sciences, Sunway University, 47500 Petaling Jaya, Malaysia
* Corresponding author: jason.d3@imail.sunway.edu.my
Breast cancers are becoming harder to treat due to the acquisition of chemo-drug resistance. In this study, silver nanoparticles (AgNPs) were synthesized using reducing agent NaBH4, where resulting nanoparticles were characterized using UV-vis spectroscopy, FTIR spectroscopy, SEM, and DLS. Cytotoxicity of synthesized AgNPs was evaluated against MCF-7, MCF-7-CR, and MDA-MB-231 using MTT assays. NaBH4-reduced AgNPs were unstable as a colloidal system, with zeta potential noted to be around -21 mV and a polydispersity index of around 15%, making them highly prone to aggregation. However, AgNPs significantly reduced the cell viability of MCF-7 breast cancer cell lines, while slight toxicity was seen in multi-drug resistant breast cancer cells MCF-7-CR and MDA-MB-231 at 10 µM.
© The Authors, published by EDP Sciences, 2024
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