E3S Web Conf.
Volume 78, 20192018 International Seminar on Food Safety and Environmental Engineering (FSEE 2018)
|Number of page(s)||5|
|Section||Food Safety, Extraction and Food Engineering|
|Published online||15 January 2019|
Study on the submerged fermentation process producing perylenequinones derivatives by shiraia sp. AL18
Shandong University of Technology, School of Life Science, 266 Xin cun xi road Zibo, 255049, China
2 Shandong University of Technology, Institute for Anti-aging & Regenerative Medicine, 266 Xin cun xi road Zibo, 255049, China
* Corresponding author: email@example.com
The perylenequinones derivatives (PQDs) are potential photosensitizers, which have a high effective light-induced biological activity, such as anti-HIV, antimicrobial and anticancer activities. In this work, the submerged fermentation process of filamentous fungus shiraia sp. AL18 producing PQDs in a stirring fermentation tank was investigated through single factor optimization. The effect of the stirring speed (450 r/min, 500 r/ min and 550 r/min at ventilation quantity for volumes of air per volume of liquid per minute (VVM) = 1:1) and ventilation quantity (VVM = 1:0.8, 1:0.65 and 1:0.5 at stirring speed of 500 r/min) on the process of submerged fermentation by stirring fermentation tank in batch fermentation was investigated using the monosyllabic test. The results suggest that the optimum stirring speed for biomass is 500 r/min and the optimum ventilation quantity for biomass is VVM = 1:0.65, and the maximum dry cell weight (DCW) reached to 19.67 g/L. The stirring speed for the optimum yield of PQDs is 500 rpm and the ventilation quantity for the optimum yield of PQDs is VVM=1: 0.8, and the maximum yield of PQDs reached to 0.3218 g/L. The yield of PQDs was correlated with pH value, dissolved oxygen (DO) value, the content of reduced sugar in the period of fermentation.
© The Authors, published by EDP Sciences, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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