E3S Web Conf.
Volume 145, 20202019 International Academic Exchange Conference on Science and Technology Innovation (IAECST 2019)
|Number of page(s)
|International Conference on Biotechnology and Food Science
|06 February 2020
The pattern of X-inactivation in Human X-linked Disorders and their Model Organisms: A literature review
Nanchang University, 461 Bayi Avenue, 330006, Nanchang, Jiangxi Province, China
* Corresponding author’s e-mail: firstname.lastname@example.org
X-inactivation is a strategy in female mammals aiming at maximizing gene inactivation of one single X chromosome in order to balance X dosage between males and females. Various human X-linked disorders have been reported related to one or more X-inactivation patterns. It is necessary to understand their relationship to study X-linked disorders. Current researches largely rely on clinical phenotype research and model organism. Considering the differences between human and model organisms, it is vital to find a suitable model of a specific disorder. The paper reviews different patterns and specific disorders linked with X-inac tivation. Also, the advantages and disadvantages of applying specific model organisms in different disorders will be discussed.
© The Authors, published by EDP Sciences 2020
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