Issue |
E3S Web Conf.
Volume 145, 2020
2019 International Academic Exchange Conference on Science and Technology Innovation (IAECST 2019)
|
|
---|---|---|
Article Number | 01023 | |
Number of page(s) | 4 | |
Section | International Conference on Biotechnology and Food Science | |
DOI | https://doi.org/10.1051/e3sconf/202014501023 | |
Published online | 06 February 2020 |
Polysaccharides from ophiopogon japonicus protect against oxidative damage induced by strenuous exercise
Department of Physical Education, Central South University, Changsha City, Hunan Province, 410083, China
a Corresponding author’s e-mail: linjinyangzn@126.com
Dry tuberous roots of ophiopogon japonicus are famous Chinese herbal medicines. Several studies have been shown that polysaccharide is one of the main active ingredients of ophiopogon japonicus and plays an important role in pharmacological action. In the study, the effects of polysaccharides from ophiopogon japonicus (POJ) on the oxidative damage induced by strenuous exercise were investigated. Male mice were randomly divided into four groups and designated as high-dose POJ-treated, medium-dose POJ-treated, low-dose POJ-treated and control groups, which received 80, 40, and 20 mg/kg POJ and physiological saline, respectively, by gavage once a day for 28 days. This was followed by an exhaustive running exercise and measurements of various biochemical parameters from blood and muscles tissue. The results showed that POJ could significantly prolong the exhaustive running time of mice, decrease the levels of lactate dehydrogenase (LDH), creatine kinase (CK) and 8-Hydroxy-2′-deoxyguanosine (8-OHdG) in blood, and malondialdehyde (MDA) levels in muscle, which were accompanied by corresponding increased levels of superoxide disproportionation enzyme (SOD), glutathione peroxidase (GPx), and catalase (CAT) in muscle. The data suggest that POJ have protective effects on strenuous exercise-induced oxidative damage.
© The Authors, published by EDP Sciences 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.