| Issue |
E3S Web Conf.
Volume 151, 2020
The 1st International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2019)
|
|
|---|---|---|
| Article Number | 01011 | |
| Number of page(s) | 5 | |
| DOI | https://doi.org/10.1051/e3sconf/202015101011 | |
| Published online | 14 February 2020 | |
Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin
1
Department of Biology Education, Faculty of Teacher Training and Education, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia.
2
Laboratory of Anatomy, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia
* Corresponding author: saf_rida@unsyiah.ac.id
This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.
Key words: cholesterol levels / glibenclamide / diabetic rat / C. papaya L
© The Authors, published by EDP Sciences, 2020
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