Toxic effects of various zinc dosages on poultry hemopoiesis

Orenburg state university, 1, 3, prospekt Pobedy, 460018, Orenburg, Russia

^* Corresponding author : kwan111@yandex.ru

Abstract

The aim of the study was to determine the main patterns of the manifestation of the toxic effect of zinc chloride on the cells of the red bone marrow in the first three days after exposure. Our experiment involved broiler chickens of the “Smena-7” cross. The work presents new data on the effects of zinc salts in doses of 40 mg/kg and 60 mg/kg on the hemopoietic cells of the red bone marrow of birds at the ultrastructural level. Thus, the results of the study showed zinc poisoning of chickens even within 1-3 days led to damage to bone marrow cells. The cytoplasm of blood-forming and stromal cells of the bone marrow detects mostly signs of destructive processes, which are amplified as the duration and the dose of exposure increase. At the same time, the structure of cell nuclei often gets changed in the bone marrow. Emerging morphological signs indicate a decrease in the transcription of ribosomal RNA genes of bone marrow cells. In the bone marrow, the number of basophil erythrokaryocytes increases and the number of hemoglobinized forms of red blood cells decreases. Zinc mainly causes disorders of morpho-functional structures in erythroblasts and mature cells of other bone marrow cell lines.