E3S Web Conf.
Volume 169, 2020Actual Problems of Ecology and Environmental Management: Cooperation for Sustainable Development and Environmental Safety (APEEM 2020)
|Number of page(s)||4|
|Published online||19 May 2020|
Environmentally-induced alternative oncogenesis: EROS arrows
Far Eastern State Medical University, Khabarovsk, Russia
2 Peoples’ Friendship University of Russia (RUDN University), Faculty of Ecology, 6 MiklukhoMaklaya St, Moscow, 117198, Russian Federation
* Corresponding author: firstname.lastname@example.org
The cause of the oncological diseases in children and the specific spectrum of this pathology, with hemangiomas prevailing among benign tumors (BT), and leukemia, lymphomas, and neural tissue tumors among malignant neoplasms (MN), remains unknown. The authors studied the similarities and differences of the connections between environmental factors, benign tumors and MN, as well as the relations between BT and MN. The causality of the so-called “sporadic” fluctuations in the incidence of neoplasms and their relations with environmental factors were revealed. A hypothesis of environmentally-induced alternative oncogenesis is suggested. According to the hypothesis, fetal hemoglobin enhances environmentally-related oxidative stress (EROS), leading to epigenomic regulation disorder of SEMA 7A and MICAL family proteins in the endothelium, axon growth cone, and hematopoietic stem cells.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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