| Issue |
E3S Web Conf.
Volume 202, 2020
The 5th International Conference on Energy, Environmental and Information System (ICENIS 2020)
|
|
|---|---|---|
| Article Number | 12004 | |
| Number of page(s) | 6 | |
| Section | Public Health and Epidemiology | |
| DOI | https://doi.org/10.1051/e3sconf/202020212004 | |
| Published online | 10 November 2020 | |
Antioxidant Potential of Kersen Leaves (Muntingia Calabura L.) Leaves to Increase Endogenous Glutathione Peroxidase (GPx) Enzymes in Diabetic Rats
Faculty of Medicine and Health Sciences, Muhammadiyah Yogyakarta University, Bantul, Yogyakarta, Indonesia
* Corresponding author: r_indriawatiwibowo@yahoo.com
The prevalence of diabetes mellitus (DM) is increasing. DM can cause an imbalance between protective antioxidants and increased production of free radicals. One such antioxidant is the endogenous enzyme glutathione peroxidase (GPx). Kersen (Muntingia calabura L.) contains flavonoids which show antioxidant activity. The purpose of this study was to examine the potential antioxidant of Kersen Leaves (Muntingia Calabura L.) leaves to GPx Enzymes in Diabetic Rats. This research is included in an experimental study with a post-test design only with control category design. The subjects of this study were 36 male rats. The measure of GDP levels using the GOD-PAP enzymatic method, while GPx uses the UV method. Data were analyzed using paired-t-test and OneWay ANOVA test. Statistical test results with paired t test showed significant differences in GDP levels before and after treatment (p = 0.0001). In the OneWay ANOVA test there was a average different GPx levels in each category (p = 0.0001). The most effective steeping increases the GPx level is a dose of 750 mg / 200 gr BW.
Key words: Kersen leaves / Muntingia Calabura L / Diabetes Mellitus / Glutathione Peroxidase / Oxidative stress
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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