E3S Web Conf.
Volume 206, 20202020 2nd International Conference on Geoscience and Environmental Chemistry (ICGEC 2020)
|Number of page(s)||4|
|Section||Earth Geological Energy Mining And Landform Protection|
|Published online||11 November 2020|
Phylogenetic and Phylogeographic Analysis of DENV-1 Genotype Ⅰ in Asian-Pacific Region
1 School of Marine and Spatial information, China University of Petroleum (east China), Qingdao 266580, China
2 Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China
* Corresponding author: email@example.com
Objective: To clarify the evolutionary characteristics and transmission mode of DENV-1 genotype I dengue virus in the Asia-Pacific region. Methods: 200 DENV-1 genotype I dengue viruses in the Asia-Pacific region from 2010 to 2014 and 2015 to 2019 were used for phylogenetic analysis and bayesian phylogeographic analysis using a series of molecular biology software. Results: DENV-1 genotype I dengue virus spread frequently between coastal cities in China and Southeast Asian countries. The evolution rate of DENV-1 genotype I dengue virus during 2010-2014 was 5.73×104 (/site/year,95%CI) , and the time to the most recent common ancestor was 1970-09-14.And the evolution rate of virus during 2015-2019 was 5.25×104 (/site/year,95%CI) , and the time to the most recent common ancestor was 1978-10-30.The virus spatial diffusion pathways shows the phenomenon that the dengue virus of this genotype is widespread in the Asia-Pacific region, the spread of the dengue virus between the coastal provinces and some inland provinces of China, and Southeast Asian countries. The study results indicated that the monitoring and preventive measures should be strengthened to avoid the threat of personal safety caused by large-scale spread of DENV-1 in China.
© The Authors, published by EDP Sciences, 2020
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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