E3S Web Conf.
Volume 233, 20212020 2nd International Academic Exchange Conference on Science and Technology Innovation (IAECST 2020)
|Number of page(s)||4|
|Section||BFS2020-Biotechnology and Food Science|
|Published online||27 January 2021|
Quorum Sensing Inhibitory Activities of Oridonin in Pseudomonas Aeruginosa
School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
* Corresponding author: email@example.com
Pseudomonas aeruginosa is an opportunistic pathogen, and it can produce cell-associated and extracellular virulence factors. Several of these virulence factors have been demonstrated to be regulated by quorum sensing (QS). Disabling QS system with anti-infective agent is considered as a potential strategy to prevent bacterial infection. Rabdosia rubescens has been used as antibacterial agents for many centuries in China. In this study, Oridonin, the major active components of Rabdosia rubescens, was tested for QS inhibition in Pseudomonas aeruginosa. QS inhibitory activity is demonstrated by reduction in pyocyanin (58.4%), rhamnolipids (64.3%), elastase (58.6%), and protease (49.1%) in Pseudomonas aeruginosa PAO1 at 125 µg/ml (MIC) concentration. Biofilm formation by Pseudomonas aeruginosa PAO1 was reduced considerably (40.3-57.7%) over control. These findings suggest that Oridonin might be a potent Quorum Sensing Inhibitor (QSI) and anti-biofilm agent in the treatment of Pseudomonas aeruginosa infections.
© The Authors, published by EDP Sciences 2021
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