| Issue |
E3S Web Conf.
Volume 328, 2021
International Conference on Science and Technology (ICST 2021)
|
|
|---|---|---|
| Article Number | 01001 | |
| Number of page(s) | 4 | |
| Section | Chemical Engineering, Physical Characteristics, Water Treatment | |
| DOI | https://doi.org/10.1051/e3sconf/202132801001 | |
| Published online | 06 December 2021 | |
Evaluation Profile In Vitro Release Gastroretentive High Density Tablet Theophylline Using Sodium Alginate and PVP
1 Departement of Pharmacy, Medical Faculty, Khairun University, 97719 South Moluccas, Indonesia
2 Departement of Mechanical Engineering, Engineering Faculty, Khairun University, 97719 South Moluccas, Indonesia
The high-density gastroretentive dosage forms was made a high-density theophylline tablets 250 mg by wet granulation method in three formulas with combine the polymer concentration. The polymer used sodium alginate and PVP K30, where the 1st formula ratio of sodium alginate: PVP K30 (18.75%: 5%), the 2nd formula ratio of sodium alginate: PVP K30 (18.75%: 2, 5%) and 3th formula ratio of sodium alginate: PVP K30 (12.5%: 2.5%). The third formula were evaluated with weight uniformity test, size uniformity test, hardness test, drug content test, in vitro release test, as well as the determination of the kinetics of drug release. The result showed the uniformity weights of the formula ranges 250.12mg-250.70mg, the uniformity size of the formula ranges 0.81cm for diameter tablet and 0.42cm-0.44cm for thick tablet, the hardness test ranges from 90N-180N. Results obtained for drug content was 106.965% formula 1st, formula 2nd is 127.625% and for formula 3th is 115.976%. Release kinetic profiles show formula 1st and 2nd used Higuchi equation and formula 3th used the first-order equation. By these three formula, 1st formula was considered the best views of drug content and release kinetics.
Key words: Gastroprotective / High Density / GRDDS / Theophylline / Sodium Alginate / PVP K30
© The Authors, published by EDP Sciences, 2021
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