| Issue |
E3S Web Conf.
Volume 244, 2021
XXII International Scientific Conference Energy Management of Municipal Facilities and Sustainable Energy Technologies (EMMFT-2020)
|
|
|---|---|---|
| Article Number | 02026 | |
| Number of page(s) | 13 | |
| Section | Resilience and Environmental Engineering | |
| DOI | https://doi.org/10.1051/e3sconf/202124402026 | |
| Published online | 19 March 2021 | |
Effect of pesticides “Butylcaptax (Russia)” and “Droppa (Russia)” on respiration and oxidative phosphorylation of liver mitochondria of pregnant rats and their embryos
1 Tashkent State Agrarian University, University str., 2, Tashkent province, Uzbekistan, 100140
2 Tashkent State Pedagogical University, Bunyodkor Road, 27, Tashkent, Uzbekistan 100183
3 Andijan State University, University str., 129, Andijan, Uzbekistan, 170100
* Corresponding author: parida.mirxamidova@mail.ru
The article provides information on the effect of pesticides - butylcaptax and droppa on respiration and oxidative phosphorylation of liver mitochondria in rat rats and their embryos. It has been shown that butylcaptax and droppa reduce the oxidation of succinate and α-ketoglutarate in the V4*, V3 and Vdnf states and drug conjugation in the liver mitochondria of pregnant animals and their embryos. The most significant inhibition of ADF formation in the respiratory chain of fatal and maternal liver mitochondria occurs via the NAD-dependent pathway, especially when poisoning with butylcaptax on the 19th day of pregnancy. Apparently, inhibition of ADF-stimulated respiration is associated with inhibition of electron transfer along the respiratory chain or is a consequence of inhibition of the transport of phosphate or ADF into mitochondria, which plays a key role in the mechanism of oxidative phosphorylation. A decrease in the conjugation of oxidation and phosphorylation does not create conditions for the accumulation of energy in an utilizable form - in the form of ADF.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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