| Issue |
E3S Web Conf.
Volume 271, 2021
2021 2nd International Academic Conference on Energy Conservation, Environmental Protection and Energy Science (ICEPE 2021)
|
|
|---|---|---|
| Article Number | 03034 | |
| Number of page(s) | 5 | |
| Section | Research on Energy Chemistry and Chemical Simulation Performance | |
| DOI | https://doi.org/10.1051/e3sconf/202127103034 | |
| Published online | 15 June 2021 | |
Screening for hub genes and signaling pathways of CD8+ T cells in systemic lupus erythematosus using bioinformatics
Zhejiang University-University of Edinburgh Institute, Zhejiang University, Haining, Zhejiang, China
* Corresponding author: flaviuswu@zju.edu.cn
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, which can damage multiple organs. The adaptive immune system, including CD8+ T cells, plays an essential role in this disease. However, the pathogenesis of SLE remains unclear, and there is a lack of effective diagnosis and treatment methods for SLE. In particular, there has been little research on SLE biomarkers, which have been widely studied and used in cancer diagnosis and treatment. In this study, bioinformatics tools were used to screen for hub genes and signaling pathways involving CD8+ T cells in patients with SLE. This is the first determination of metabolic abnormalities in SLE CD8+ T cells using bioinformatics pathway enrichment analysis. The PPI network and MCC algorithm identified SKP2 as a potential biomarker for SLE.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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