| Issue |
E3S Web Conf.
Volume 271, 2021
2021 2nd International Academic Conference on Energy Conservation, Environmental Protection and Energy Science (ICEPE 2021)
|
|
|---|---|---|
| Article Number | 03051 | |
| Number of page(s) | 4 | |
| Section | Research on Energy Chemistry and Chemical Simulation Performance | |
| DOI | https://doi.org/10.1051/e3sconf/202127103051 | |
| Published online | 15 June 2021 | |
Regulation of autophagy during mitosis
College of Nature Science, University of Massachusetts Amherst, Amherst Massachusetts 01003, U.S.
* Corresponding author: yikanggong@umass.edu
Based on observations of mitosis process, it has been implied that autophagy is repressed. Because the integrity of chromosomes and proteins are significant for cell cycle, the repression of autophagy serves as a protection. However, the mechanistic detail of whether and how autophagy is regulated during mitosis remains controversial. In this review, we aim to analyse and review the recent literature on the regulation of autophagy during mitosis. According to researches, autophagy is repressed via inhibitory phosphorylation of autophagy genes by CDK1, CUL4-RING ubiquitin ligases-mediated and WIPI2 polyubiquitination and proteasomal degradation. In addition, the recent evidence that indicates autophagy is repressed will be reviewed.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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