| Issue |
E3S Web Conf.
Volume 290, 2021
2021 3rd International Conference on Geoscience and Environmental Chemistry (ICGEC 2021)
|
|
|---|---|---|
| Article Number | 01028 | |
| Number of page(s) | 4 | |
| Section | Environmental Chemistry and Chemical Technology Application | |
| DOI | https://doi.org/10.1051/e3sconf/202129001028 | |
| Published online | 14 July 2021 | |
Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
School of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015, China Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying University, Meizhou, Guangdong 514015, China
* Corresponding author: 198601012@jyu.edu.cn
In acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, Fe(Ⅱ) reacts with 2,2'-bipyridine to form an orange complex with a maximum absorption wavelength of 522 nm. According to this principle, the content of isoniazid can be measured indirectly by measuring the amount of Fe(Ⅱ). A new method for the determination of isoniazid by Fe(Ⅱ)-2,2'-bipyridine spectrophotometry has been established. At the optimum conditions, the linear relationship is good between the mass concentration of isoniazid and absorbance of Fe(Ⅱ)-2,2'-bipyridine complex in the range of 0.0004000-0.002800 mg/mL. The linear regression equation is A=0.0251+138.04C(mg/mL), and the linear correlation coefficient is 0.9995. This method is used to determine the content of isoniazid in isoniazid tablets, and the results are similar to those obtained by pharmacopoeia method.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.