E3S Web Conf.
Volume 292, 20212021 2nd International Conference on New Energy Technology and Industrial Development (NETID 2021)
|Number of page(s)||4|
|Section||Environmental Sustainable Development and Industrial Transformation|
|Published online||09 September 2021|
Effect of moxifloxacin on pharmacokinetics of enalapril in rats
1 Northwest Minzu University Hospital, 730030 Lanzhou, China
2 Northwest Minzu University Hospital, 730030 Lanzhou, China
* Corresponding author: firstname.lastname@example.org
The purpose of this study was to investigate the effect of moxifloxacin on the pharmacokinetics of enalapril. Single administration experiment: 12 Wistar rats were randomly divided into two groups on average. Control group: enalapril (15mg/kg)+ normal saline combined group: enalapril (15mg/kg)+ moxifloxacin (80mg/kg), intragastric administration. Blood samples were measured by LC-MS/MS. Multiple administration experiment: 12 Wistar rats were randomly divided into two groups on average. The control group was given normal saline (day1-7)+ enalapril (day8,15mg/kg), and the combination group was given moxifloxacin (day1-7, 80mg/kg)+ enalapril (day8,15mg/kg) by intra-gastric administration. The treatments were the same as above. Pharmacokinetics parameters were calculated using Winnonlin 6.1 software and the two groups were compared using SPSS18.0 software. In single administration experiment compared with the control group, the AUC(0-t) and Cmax of enalapril were decreased by 31.99%（P<0.05), 42.57% (P<0.05) in the combined administration group. Quinolone antibiotics and ACEI drugs should not be taken at the same time during clinical treatment to avoid drug interactions that may occur when combined drugs are used.
© The Authors, published by EDP Sciences, 2021
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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