| Issue |
E3S Web Conf.
Volume 385, 2023
2023 8th International Symposium on Energy Science and Chemical Engineering (ISESCE 2023)
|
|
|---|---|---|
| Article Number | 04001 | |
| Number of page(s) | 5 | |
| Section | Polymer Chemistry and Chemical Research Progress | |
| DOI | https://doi.org/10.1051/e3sconf/202338504001 | |
| Published online | 04 May 2023 | |
Studies on Chemical Constituents of Radix Angelicae pubescentis
1 College of commerce Liaoning economic management cadre Institute Shenyang, China
2 Endocrinology department Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang, China
3 College of pharmacy Liaoning University of Traditional Chinese Medicine Dalian, China
a 46581081@qq.com
b 820331@qq.com
*c Corresponding author: qingyang-tcm@163.com
Backgound:Angelicae pubescentis is the root of Angelica pubescens Maxim. f. biserrata Shan et Yuan. The main active ingredients are coumarin and volatile oil, and it has a variety of pharmacological activities such as antibacterial, antioxidant and anti-inflammatory. In this paper, the active components of the CO2 supercritical extract of Angelicae pubescentis were studied. The results of this study will provide a scientific basis for the study of the chemical composition of Angelicae pubescentis. Purpose: To study the chemical constituents of supercritical extract of Radix Angelicae pubescentis. Method: The supercritical extract of Radix Angelicae pubescentis was separated by silica gel column chromatography to obtain monomers. The structures were identified based on physicochemical properties and spectroscopic data. Result: Eight compounds were separated from the supercritical extract of Radix Angelicae pubescentis, six of which were identified.They are Osthol, Columbianedin, Columbianetin, Columbianetin Acetate, Xanthotoxin and Bergapten. Conclusion: Xanthotoxin and Bergapten were isolated, which structure were similar. The standard substance of Osthol and Columbianedin were producted in order to offer the good material base for quality evaluation and pharmacodynamic study of Radix Angelicae pubescentis. Their purification were more than 99%. The results of this study are of great significance for exploring the effective material basis and medicinal value of the supercritical extract of Radix Angelicae pubescentis.
© The Authors, published by EDP Sciences, 2023
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