Determination of Oxidative Stress Markers in Women with Polycystic Ovarian Syndrome

Department of Optical Techniques, AlNoor University College, Nineveh, Iraq

^* Corresponding Author: researcherstaff05@alnoor.edu.iq

Abstract

Polycystic ovarian syndrome (PCOS) is a condition that increases the risk of metabolic diseases, such as insulin resistance, diabetes mellitus, and obesity, among others. Oxidative stress is a state of elevated oxidants and reduced antioxidants, which can be detrimental to the body. Reduced glutathione (GSH) is an important material with antioxidant properties. This study aimed to investigate the status of oxidative stress in PCOS women by measuring total oxidant status (TOS) and GSH in their serum, and explore the possibility of using oxidative stress biomarkers in the diagnosis of the disease. The study included 60 women with PCOS and 30 women without PCOS as controls. PCOS women had significantly higher values of body mass index, testosterone, and TOS, while GSH levels were significantly reduced. There was also a significant negative correlation between TOS and GSH levels in PCOS women. These findings indicate that PCOS women exhibit systemic oxidative stress, and suggest the use of anti-oxidative drugs to manage the health consequences of PCOS. The study demonstrates the excellent sensitivity of TOS and GSH as prognostic biomarkers for PCOS.