E3S Web Conf.
Volume 416, 20233rd International Conference on Oil & Gas Engineering and Geological Sciences (OGEGS 2023)
|Number of page(s)||5|
|Published online||10 August 2023|
Preparation and study of modified polyethyleneimine cationic adjuvant
1 Institute of Energy Resources, Hebei Academy of Sciences, Shijiazhuang, Hebei Province, China
2 School of Materials Science and Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei Province, China
3 Shijiazhuang Polymer Composite Technological Innovation Center, College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei Province, China
4 Institute of Biology, Hebei Academy of Sciences, Shijiazhuang, Hebei Province, China
* Corresponding author: firstname.lastname@example.org
A polyethylenimine adjuvant modified by mannose, which may be used in the study of vaccine adjuvant, was prepared in this paper. Its structure was characterized by infrared spectroscopy and its micromorphology was observed by transmission electron microscopy. A series of mannose-modified polyvinylimine were prepared according to the molar ratio of primary amine groups between mannose and polyvinylimine, and their storage stability was observed at 4°C. In addition, the cytotoxicity of modified and unmodified polyethylenimine was also tested, and the results showed that the modified polyethylenimine was less toxic than unmodified polyethylenimine.
Key words: Adjuvant / mannose / polyethyleneimine / cytotoxicity
© The Authors, published by EDP Sciences, 2023
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