| Issue |
E3S Web Conf.
Volume 442, 2023
International Seminar on Fish and Fisheries Sciences (ISFFS 2023)
|
|
|---|---|---|
| Article Number | 02025 | |
| Number of page(s) | 13 | |
| Section | Aquaculture | |
| DOI | https://doi.org/10.1051/e3sconf/202344202025 | |
| Published online | 09 November 2023 | |
Determination of withdrawal time, efficacy, and safety test of enrofloxacin in carp (Cyprinus carpio)
1 Research Center for Fishery, National Research and Innovation Agency, Jl. Raya Bogor KM 46, Bogor, Indonesia
2 Center for Examination of Fish Health and Environment, KKP, Jl. Raya Carita, Banten, Indonesia
* Corresponding author: manj001@brin.go.id
The use of antibiotic such as enrofloxacin for the treatment of fish diseases needs to be appropriately controlled so that the medicine function effectively and does not cause antibiotic residues above the maximum residues limit (MRL). The study aims to determine the duration of administration, efficacy, and safety of enrofloxacin in carp. The size of the carp used was 10-40 g, with a length of 8-12 cm. The methods used in this study were (a) withdrawal time test, (b) efficacy and safety test, and (c) histopathology analysis. The results of determining enrofloxacin withdrawal time for 0.5 MRL and 1 MRL were two days and eight days, respectively. The survival rates of carp in post-challenge with Aeromonas hydrophila for the positive control and efficacy groups were 86.7% and 88.9%, respectively, and were not significantly different. The results of histopathological observations on the liver, spleen, kidney, and muscle of the carp showed no significant pathological changes between the safety test dose treatment and the control treatment.
Key words: Aeromonas hydrophila / enrofloxacin / carp / withdrawal time
© The Authors, published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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