| Issue |
E3S Web Conf.
Volume 460, 2023
International Scientific Conference on Biotechnology and Food Technology (BFT-2023)
|
|
|---|---|---|
| Article Number | 07029 | |
| Number of page(s) | 6 | |
| Section | Energy Engineering and Renewable Energy | |
| DOI | https://doi.org/10.1051/e3sconf/202346007029 | |
| Published online | 11 December 2023 | |
Large amplitude density fluctuations in a lipid bilayer, induced by picosecond electric pulses, and their possible biotechnological applications
Federal Research Center “Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences”, 660036 Krasnoyarsk, Russia
* Corresponding author: zakhvataev.ve@ksc.krasn.ru
Electroporation refers to changes in permeabilization of lipid membranes induced by external pulsed electric fields. Diverse applications of electroporation in biotechnology include gene transfer, modulation of gene expression, cell proliferation, seed germination, sterilization in the food industry, and extraction of chemical compounds. We argue that the formation of large amplitude, subnanometer density fluctuations in lipid bilayers, induced by high-intensity pulsed electric fields with picosecond durations, may produce lipid nanopores and change transmembrane transport, which trigger cellular signalling pathways with subsequent cellular responses and changes in cell physiology, thus, could represent perspectives regarding the development of electroporation biotechnologies.
© The Authors, published by EDP Sciences, 2023
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