Issue |
E3S Web Conf.
Volume 474, 2024
X International Annual Conference “Industrial Technologies and Engineering” (ICITE 2023)
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Article Number | 03008 | |
Number of page(s) | 7 | |
Section | Agricultural Sciences and Environment | |
DOI | https://doi.org/10.1051/e3sconf/202447403008 | |
Published online | 08 January 2024 |
Synthesis and study of the antifungal activity of 1-(2-cyanophenyl)-3-heterylureas
Ural Federal University of the first President of Russia B. N. Yeltsin, Institute of Chemical Technology, Yekaterinburg, Russia
* Corresponding author: t.v.glukhareva@urfu.ru
In the treatment and prevention of fungal infections of plants, along with fungicides, inducers of systemic plant resistance, also called elicitors, have become particularly important in recent years. In this work, a method was developed for the synthesis of new 3,4-dichloroisothiazol-5-yl and 4-methyl-1,2,3-thiadiazol-5-yl ureas 1,2, containing a 2-cyanophenyl substituent, structurally similar to a known synthetic elicitors isotianil and tiadinil. The protective properties of the obtained compounds on cucumber and pepper leaves infected with B. cinerea, as well as their fungicidal properties against B. cinerea, were studied. It has been established that disubstituted ureas 1,2 exhibit very low fungicidal activity against this fungus, about 11%. At the same time, study on plant leaves showed that compound 2 effectively inhibited the development of gray mold on both cucumber and pepper leaves with an inhibition rate of more than 90%, which was similar to tiadinil. Compound 1 was effective only on cucumber leaves (96.50±0.01%). Isotianil in the experiment showed an average degree of protection – 62.48±1.04% on cucumber leaves and 56.50±1.29% on pepper leaves.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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