Issue |
E3S Web Conf.
Volume 503, 2024
The 9th International Symposium on Applied Chemistry in conjuction with the 5th International Conference on Chemical and Material Engineering (ISAC-ICCME 2023)
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Article Number | 07002 | |
Number of page(s) | 8 | |
Section | Organic and Natural Product Chemistry | |
DOI | https://doi.org/10.1051/e3sconf/202450307002 | |
Published online | 20 March 2024 |
Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs
1 Department of Chemistry, Faculty of Mathematics and Natural Sciences (FMIPA), University of Indonesia, Depok, Indonesia
2 Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency of Indonesia (BRIN), KST BJ Habibie, Puspiptek, South Tangerang, Indonesia
3 Research Center for Biosystematics and Evolution, National Research and Innovation Agency of Indonesia (BRIN), Cibinong Science Center, KST Soekarno, Cibinong, Indonesia
4 Research Center for Chemistry,National Research and Innovation Agency of Indonesia (BRIN), KST BJ Habibie, Puspiptek, South Tangerang, Indonesia
* Corresponding author: sumi.hudiyono@sci.ui.ac.id
The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (non-polar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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