Biomaterials for Artificial Organs and Organoids- A Comprehensive review

¹ Institute of Aeronautical Engineering, Dundigal, Hyderabad, India
² Mechanical Engineering, New Horizon College of Engineering, Bangalore, India
³ Department of Mechanical and Allied Engineering, IILM University, Greater Noida
⁴ Lovely Professional University, Phagwara, India
⁵ Lloyd Institute of Engineering & Technology, Greater Noida, Uttar Pradesh 201306
⁶ Lloyd Institute of Management and Technology, Greater Noida, Uttar Pradesh, India - 201306
⁷ Hilla university college, Babylon, Iraq

^* Corresponding author: anky22cool@gmail.com

Abstract

The technological development of biomaterials used in forming artificial organs and organoids indicates a revolutionary area within biomedical engineering and the field of regenerative medicine. This study provides an in-depth review of recent progress in biomaterials, emphasizing their design and use for fabricating artificial organs and organoids. The analysis proceeds with examining the necessary parameters for biomaterials in simulating the biological and biomechanical qualities of local tissues. The next effort turns towards synthesizing and characterizing innovative biomaterials, including biocompatible polymers, hydrogels, and bioactive scaffolds that can be tailored to suit specific organ systems. The paper provides an in-depth take on the developments in 3D biological printing and microfabrication techniques, emphasizing how they facilitate the synthesis of complicated, multicellular structures. The research also examines the integration of biomaterials when combined with stem cell technologies, focusing on their role in forming organs and the prospects for customized medical treatments. This review highlights the significant developments achieved in this area and the potential of these technologies in addressing the limited supply of organs, performing drug testing, and improving knowledge of the growth of organs and diseases.