Sustainable deployment of host defense peptides for targeted quorum sensing inhibition

Department of Chemistry, UIS, Chandigarh University, Mohali, Punjab, India

Abstract

The intriguing fact is that exploration of Host Defense Peptides (HDPs), usually known as antimicrobial peptides, has become increasing because of their multifaceted nature, which makes them extremely important for immunity and possible medication. HDPs are short peptides which are produced by the human body as well as other organisms and part of the immune system of the organism that is where they play an essential role. The peptides flexibly promote the antimicrobial resistance to different bacteria, fungi, viruses, and parasites. The main mechanisms work via microorganism cell membrane disruption, perturbation of nucleic acid synthesis, and modulation of the immune response. It is important to mention that the application of HDPs is a fleeting remedy to antibiotics counteracting the development of antibiotics resistance. The fact that they can attack the pathogenic biofilms which are particularly difficult target of conventional therapeutics is undoubtedly additional benefit of using biophotons for clinical purposes – they would be highly helpful in the therapy of chronic diseases and wound healing. HDPs’ sustainability is reinforced by its biodegradability and practically no environmental impacts compared to pharmaceuticals based on the chemical elements that is the major concern in the medical sphere nowadays. Their diverse functions and the respective efficacy against resistant strains are very much active research activities right now, thereby making clear the role of these probiotics in addressing the present and future health hurdles.