Research of Organ-on-a-chip and its application

Department of Biochemical Engineering, University College London, London, United Kingdom

^* Corresponding author: zcbessu@ucl.ac .uk

Abstract

Material selection for Organ-on-a-Chip fabrication is a complex process, necessitating careful consideration of multiple factors. This comprehensive assessment involves detailed scrutiny of five materials—PDMS, glass, silicon, hydrogel, and PMMA—each accompanied by an intricate exploration of their specific properties. Moreover, thoroughly evaluating the associated costs contributes to the decision-making process, ensuring optimal material choices aligned with the intended applications. Furthermore, this discourse extends to an in-depth discussion of distinct organoids, including lung, liver, kidney, and skin chips. This comprehensive analysis delves into the principles underpinning their functionality, the intricate structures replicating organ features, and a forward-looking evaluation of their development prospects. By delving into the essence of each organoid, a holistic understanding of their potential in revolutionizing disease modeling, drug testing, and personalized medicine is elucidated. The narrative culminates in the introduction of the groundbreaking combined multi-organic chip system. This integration of various organoid models represents a significant stride towards emulating the interconnectedness of organs within the human body. This futuristic approach lays the foundation for a dynamic and intricate system that provides a holistic view of complex physiological interaction.