Issue |
E3S Web of Conf.
Volume 553, 2024
2024 International Conference on Ecological Protection and Environmental Chemistry (EPEC 2024)
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Article Number | 05036 | |
Number of page(s) | 6 | |
Section | Medical Treatments and Therapies | |
DOI | https://doi.org/10.1051/e3sconf/202455305036 | |
Published online | 24 July 2024 |
Theories of Alzheimer’s disease: Amyloid hypothesis, blood-brain barrier hypothesis and cholinergic hypothesis
1 Nanjing Foreign Language School, No. 30, Beijing East Road, Xuanwu District, Nanjing, China
2 Newbury Park Highschool, 456 N Reino Rd, Newbury Park CA 91320, USA
3 Cogdel Cranleigh High School, No.9 Tianyu Road, Panlongcheng Economic Development Zone, Wuhan, China
* Corresponding author: jweis52726@student.napavalley.edu
Alzheimer’s disease (AD) is the biggest drain on society’s resources in the developed world. AD accounts for between 60 and 80 percent of dementia cases in older persons, making it the most prevalent cause of dementia. This paper analyzes three theories and experiments about AD, which are amyloid hypothesis, blood-brain barrier (BBB) hypothesis and cholinergic hypothesis. The amyloid hypothesis suggests that cognitive decline in patients is caused by the accumulation of amyloid beta (Aβ), which creates plaques that block the efficient transmission of neuronal signals. The BBB hypothesis suggests that the breakdown of the integrity of the BBB allows harmful substances and immune cells to enter the brain, causing inflammation and neuronal damage, which leads to cognitive decline in Alzheimer’s patients. The cholinergic hypothesis proposes that AD is caused by the nervous system’s reduced production of the neurotransmitter acetylcholine.
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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