Proliferative activity of normal tissues and malignant tumors during infestation of the organism by a biotic ecopathogen

Tyumen State Medical University, Ministry of Health of Russia, Tyumen, Russia

^* Corresponding author: rybkaag@tyumsmu.ru

Abstract

The article shows the role of metabolites of metacercariae and opisthorchiae in the induction of proliferative activity of somatic cells of the hepatobiliary system and other organs. The importance of cellular and tissue bioregulators in increasing the level of proliferative activity of various tissues in organisms infested by the trematode Opisthorchis felineus is considered. It follows from the data obtained that the biological function of a tissue-specific keilon–containing effector produced by differentiated cells and inhibiting cell proliferation based on the biological feedback principle, in comparison with the background of prolonged parasitization of this ecopathogenic helminth in the hepatobiliary system of the body, decreases. There is also a decrease in the sensitivity of somatic cells to a tissue-specific growth inhibiting factor. It follows that the activation of cellular and tissue proliferation of animals longterm infested by opisthorchiasis is also due to a violation of the mechanisms of regulation of cellular and tissue homeostasis. This is confirmed by an increase in the growth rate of syngenic malignant tumors, as well as a modification of the effect of homologous leukocyte interferon from an inhibitor of the malignant process to an activator.