Issue |
E3S Web Conf.
Volume 556, 2024
International Conference on Recent Advances in Waste Minimization & Utilization-2024 (RAWMU-2024)
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Article Number | 01051 | |
Number of page(s) | 9 | |
DOI | https://doi.org/10.1051/e3sconf/202455601051 | |
Published online | 09 August 2024 |
Synthesis and SAR of morpholine and its derivatives: A review update
1 Delhi Transport Corporation, New Delhi, India - 144411
2 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi GT-Road, Phagwara, Punjab 144411
* Corresponding author Email: sanjeev.24026@lpu.co.in
Morpholine is a stretchy moiety, a special pharmacophore and an amazing heterocyclic compound with wide scopes of pharmacological exercises because of various pharmacological of activity. The capacity of morpholine to upgrade the power of the particle through sub-atomic collaborations with the objective protein (kinases) or to modify the pharmacokinetic properties impelled restorative scientific experts and specialists to orchestrate morpholine ring by the proficient ways and to fuse this moiety to create different lead compound with assorted therapeutic activity. Morpholine is an organic substance compound having a six-membered ring containing two heteroatom nitrogen(N) and oxygen(O), considered as the significant core in restorative and medicinal chemistry. The current study essentially centered around talking about the most encouraging synthesis leads containing compound morpholine ring alongside structure-activity relationship (SAR) to uncover the dynamic pharmacophores responsible for anticancer, mitigating, antiviral, anticonvulsant, antihyperlipidemic, cell reinforcement, antimicrobial and antileishmanial action. This audit will give the essential information base to the medicinal chemistry in rolling out vital basic improvements in structuring morpholine subsidiaries.
Key words: Heterocyclic Compounds / Morpholine / SAR / Synthesis
© The Authors, published by EDP Sciences, 2024
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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