Issue |
E3S Web Conf.
Volume 608, 2025
EU-CONEXUS EENVIRO Research Conference - The 9th Conference of the Sustainable Solutions for Energy and Environment (EENVIRO 2024)
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Article Number | 03003 | |
Number of page(s) | 9 | |
Section | Medical Biology and Pharmacy | |
DOI | https://doi.org/10.1051/e3sconf/202560803003 | |
Published online | 22 January 2025 |
The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions
1 Department of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh.Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic
2 Department of Pharmaceutical Chemistry and Drug Technology, Osh State University, Osh, Kyrgyz Republic
* Corresponding author: gasrankulova@oshsu.kg
In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. In particular, a decrease in prothrombin time, prothrombin index, thrombin time and activated partial thromboplastin time, and a decrease in ADP concentration in old rats were observed. Consequently, the obtained results indicate the hypocoagulant effect of coenzyme Q10 in the hemostasis system in old rats.
Key words: high altitude / old rats / oxidative stress / hemostasis / coenzyme Q10
© The Authors, published by EDP Sciences, 2025
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