| Issue |
E3S Web Conf.
Volume 608, 2025
EU-CONEXUS EENVIRO Research Conference - The 9th Conference of the Sustainable Solutions for Energy and Environment (EENVIRO 2024)
|
|
|---|---|---|
| Article Number | 03003 | |
| Number of page(s) | 9 | |
| Section | Medical Biology and Pharmacy | |
| DOI | https://doi.org/10.1051/e3sconf/202560803003 | |
| Published online | 22 January 2025 | |
The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions
1 Department of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh.Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyz Republic
2 Department of Pharmaceutical Chemistry and Drug Technology, Osh State University, Osh, Kyrgyz Republic
* Corresponding author: gasrankulova@oshsu.kg
In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. In particular, a decrease in prothrombin time, prothrombin index, thrombin time and activated partial thromboplastin time, and a decrease in ADP concentration in old rats were observed. Consequently, the obtained results indicate the hypocoagulant effect of coenzyme Q10 in the hemostasis system in old rats.
Key words: high altitude / old rats / oxidative stress / hemostasis / coenzyme Q10
© The Authors, published by EDP Sciences, 2025
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.