| Issue |
E3S Web Conf.
Volume 633, 2025
International Forum of Global Advances in Sustainable Environment, Energy, and Earth Sciences (GASES 2025)
|
|
|---|---|---|
| Article Number | 01002 | |
| Number of page(s) | 5 | |
| Section | Sustainable Resource Management | |
| DOI | https://doi.org/10.1051/e3sconf/202563301002 | |
| Published online | 04 June 2025 | |
High-performance liquid chromatography method for the determination of levofloxacin in liquid pharmaceutical preparations: Implications for environmental health and earth sciences
1 National University of Uzbekistan named after Mirzo Ulugbek, 50140501 Tashkent, Uzbekistan
2 Tashkent State Technical University, 70720601 Tashkent, Uzbekistan
* Corresponding author: arazberdiyevas@gmail.com
Analytical testing is integral to evaluating pharmaceutical quality and efficacy, with important ramifications for both public health and environmental protection. This study details the development and validation of an HPLC method for quantifying levofloxacin in liquid pharmaceutical formulations, employing a 5 μm (150 × 3.9 mm) C18 reversed-phase column and a UV-visible detector. Gradient chromatography was performed over 25 minutes at a flow rate of 1.0 mL/min, with detection at 275 nm. Method validation used OpenLab ChemStation ver. A.01.05 and adhered to international guidelines, confirming the approach’s accuracy, linearity, specificity, and robustness. The results have implications for monitoring pharmaceutical residues in the environment, which is critical to safeguarding water resources and maintaining ecological balance in Earth sciences.
© The Authors, published by EDP Sciences, 2025
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