Open Access
E3S Web Conf.
Volume 251, 2021
2021 International Conference on Tourism, Economy and Environmental Sustainability (TEES 2021)
Article Number 02033
Number of page(s) 7
Section Environmental Ecological Analysis and Sustainable Development Research
Published online 15 April 2021
  1. Siegel, R., Ma J., Zou Z., Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64(1):9–29. PubMed PMID:24399786. [Google Scholar]
  2. Kirkwood, J.M., Butterfield L.H., Tarhini A.A., Zarour H., Kalinski P., Ferrone S. Immunotherapy of cancer in 2012. CA Cancer J Clin. 2012;62(5):309–335. doi: 10.3322/caac.20132 [Google Scholar]
  3. Gajewski, T.F., Schreiber H., Fu, Y.X. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–1022. doi: 10.1038/ni.2703 [Google Scholar]
  4. Fox, B.A., Schendel D.J., Butterfield L.H., et al. Defining the critical hurdles in cancer immunotherapy. J Transl Med 2011;9(1):214. PubMed PMID:22168571. [Google Scholar]
  5. Scanlan, M.J., Gure A.O., Jungbluth A.A., Old L.J., Chen, Y.T. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev. 2002;188:22–32. doi: 10.1034/j.1600-065x.2002.18803.x [Google Scholar]
  6. Q. Zhao, O.L. Caballero, A.J.G. Simpson, R.L. Strausberg Differential evolution of MAGE genes based on expression pattern and selection pressure PLoS One, 7 (2012), p. e48240 [Google Scholar]
  7. B.J. Stevenson, C. Iseli, S. Panji, M. Zahn-Zabal, W. Hide, L.J. Old, et al. Rapid evolution of cancer/testis genes on the X chromosome BMC Genomics, 8 (2007), p. 129 [Google Scholar]
  8. Ross, M.T., Grafham D.V., Coffey A.J., et al. The DNA sequence of the human X chromosome. Nature. 2005;434(7031):325–337. doi: 10.1038/nature03440 [Google Scholar]
  9. L.G. Almeida, N.J. Sakabe, A.R. DeOliveira, M.C.C. Silva, A.S. Mundstein, T. Cohen, et al. CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens Nucleic Acids Res., 37 (2009), pp. D816–D819 [Google Scholar]
  10. van der Bruggen, P., Traversari, C., Chomez, P., Lurquin, C., De Plaen, E., Van den Eynde, B., Knuth, A., and Boon, T. (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science (New York, N.Y 254, 1643–1647 PMID 1840703 [Google Scholar]
  11. Anil Suri (2006) Cancer testis antigens - their importance in immunotherapy and in the early detection of cancer, Expert Opinion on Biological Therapy, 6:4, 379–389, DOI: 10.1517/14712598.6.4.379 [Google Scholar]
  12. Chen, Y. T., Stockert, E., Chen, Y., Garin-Chesa, P., Rettig, W. J., van der Bruggen, P., Boon, T., and Old, L.J. (1994) Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America 91, 1004–1008 PMID 8302824 [Google Scholar]
  13. De Smet, C., Lurquin, C., van der Bruggen, P., De Plaen, E., Brasseur, F., and Boon, T. (1994) Sequence and expression pattern of the human MAGE2 gene. Immunogenetics 39, 121–129 PMID 8276455 [Google Scholar]
  14. Boël, P., Wildmann C., Sensi M.L., et al. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity. 1995;2(2):167–175. doi: 10.1016/s1074-7613(95)80053-0 [Google Scholar]
  15. De Backer, O., Arden K.C., Boretti M., et al. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. Cancer Res. 1999;59(13):3157–3165. [Google Scholar]
  16. Chen, Y.T., Gure A.O., Tsang S., et al. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci USA 1998;95(12):6919–6923. PubMed PMID:9618514. [Google Scholar]
  17. Li, G., Miles A., Line A., Rees RC. Identification of tumour antigens by serological analysis of cDNA expression cloning. Cancer Immunol Immunother 2004;53(3):139–143. PubMed PMID:14722670. [Google Scholar]
  18. Chen, Y. T., Scanlan, M. J., Sahin, U., Tureci, O., Gure, A. O., Tsang, S., Williamson, B., Stockert, E., Pfreundschuh, M., and Old, L. J. (1997) A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proceedings of the National Academy of Sciences of the United States of America 94, 1914–1918 PMID 9050879 [Google Scholar]
  19. Raza, A., Merhi M., Inchakalody V.P., et al. Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy. J Transl Med. 2020;18(1):140. Published 2020 Mar 27. doi: 10.1186/s12967-020-02306-y [Google Scholar]
  20. Türeci, O., Sahin U., Schobert I., et al. The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40. Cancer Res. 1996;56(20):4766–4772. [Google Scholar]
  21. Alsheimer, M., Drewes T., Schütz W., Benavente R. The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa. Eur J Cell Biol. 2005;84(2-3):445–452. doi: 10.1016/j.ejcb.2004.11.003 [Google Scholar]
  22. Wobus, M., List C., Dittrich T., et al. Breast carcinoma cells modulate the chemoattractive activity of human bone marrow-derived mesenchymal stromal cells by interfering with CXCL12. Int J Cancer. 2015;136(1):44–54. doi: 10.1002/ijc.28960 [Google Scholar]
  23. Zhu, F., Bo H., Liu G., Li R., Liu Z., Fan L. SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells. PeerJ. 2020;8:e9358. Published 2020 Jun 23. doi: 10.7717/peerj.9358 [Google Scholar]
  24. Mahmoud AM. Cancer testis antigens as immunogenic and oncogenic targets in breast cancer. Immunotherapy. 2018;10(9):769–778. doi: 10.2217/imt-2017-0179 [Google Scholar]
  25. Atanackovic, D., Blum I., Cao Y., et al. Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. Cancer Biol Ther. 2006;5(9):1218–1225. doi: 10.4161/cbt.5.9.3174 [Google Scholar]
  26. Chen, Y.T., Ross D.S., Chiu R., et al. Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers. PLoS One. 2011;6(3):e17876. Published 2011 Mar 18. doi: 10.1371/journal.pone.0017876 [Google Scholar]
  27. Maheswaran, E., Pedersen C.B., Ditzel H.J., Gjerstorff MF. Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer. PLoS One. 2015;10(8):e0134967. Published 2015 Aug 7. doi: 10.1371/journal.pone.0134967 [Google Scholar]
  28. Lim, J., Goriely A., Turner G.D., et al. OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol. 2011;224(4):473–483. doi: 10.1002/path.2919 [Google Scholar]
  29. Chen, Y.T., Panarelli N.C., Piotti K.C., Yantiss, R.K. Cancer-testis antigen expression in digestive tract carcinomas: frequent expression in esophageal squamous cell carcinoma and its precursor lesions. Cancer Immunol Res. 2014;2(5):480–486. doi: 10.1158/2326-6066.CIR-13-0124 [Google Scholar]
  30. Faramarzi, S., Ghafouri-Fard S. Melanoma: a prototype of cancer-testis antigen-expressing malignancies. Immunotherapy. 2017;9(13):1103–1113. doi: 10.2217/imt-2017-0091 [Google Scholar]
  31. Gezgin, G., Luk S.J., Cao, J. et al. PRAME as a potential target for immunotherapy in metastatic uveal melanoma. JAMA Ophthalmol. 135(6), 541–549 (2017). [Google Scholar]
  32. Svobodovâ, S., Browning J., Macgregor, D. et al. Cancer-testis antigen expression in primary cutaneous melanoma has independent prognostic value comparable to that of Breslow thickness, ulceration and mitotic rate. Eur. J. Cancer 47(3), 460–469 (2011). [Google Scholar]
  33. Zhang, Y., Zhang Y., Zhang L. Expression of cancer-testis antigens in esophageal cancer and their progress in immunotherapy. J Cancer Res Clin Oncol. 2019;145(2):281–291. doi: 10.1007/s00432-019-02840-3 [Google Scholar]
  34. Gjerstorff, M.F., Pohl M., Olsen K.E., Ditzel, H.J. Analysis of GAGE, NY-ESO-1 and Sp17 cancer/testis antigen expression in early stage non-small cell lung carcinoma. BMC Cancer. 2013;13:466. Published 2013 Oct 8. doi: 10.1186/1471-2407-13-466 [Google Scholar]
  35. Xie, K., Fu C., Wang S., et al. Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets. J Ovarian Res. 2019; 12(1):1. Published 2019 Jan 4. doi: 10.1186/s13048-018-0475-z [Google Scholar]
  36. Veit, J.A., Heine D., Thierauf J., et al. Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck. Head Neck. 2016;38(7):1008–1016. doi: 10.1002/hed.24403 [Google Scholar]
  37. Laban, S., Atanackovic D., Luetkens T., et al. Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer. Int J Cancer. 2014;135(5):1142–1152. doi: 10.1002/ijc.28752 [Google Scholar]
  38. Li, Y., Li J., Wang Y., et al. Roles of cancer/testis antigens (CTAs) in breast cancer. Cancer Lett. 2017;399:64–73. doi: 10.1016/j.canlet.2017.02.031 [Google Scholar]
  39. Yao, J., Caballero O.L., Yung W.K., et al. Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers. Cancer Immunol Res. 2014;2(4):371–379. doi: 10.1158/2326-6066.CIR-13-0088 [Google Scholar]
  40. Caron, C., Lestrat C., Marsal S., et al. Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. Oncogene. 2010;29(37):5171–5181. doi: 10.1038/onc.2010.259 [Google Scholar]
  41. Pellon-Maison, M., Montanaro M.A., Lacunza E., et al. Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line. PLoS One. 2014;9(6):e100896. Published 2014 Jun 26. doi: 10.1371/journal.pone.0100896 [Google Scholar]
  42. De Smet, C., Lurquin C., Lethe B., Martelange V., Boon T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol. 1999;19(11):7327–7335. doi: 10.1128/MCB.19.11.7327. [Google Scholar]
  43. Karpf AR. A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy. Epigenetics. 2006;1(3):116–120. doi: 10.4161/epi.1.3.2988. [Google Scholar]
  44. De Smet, C., De Backer O., Faraoni I., Lurquin C., Brasseur F., Boon T. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci US A. 1996;93(14):7149–7153. doi: 10.1073/pnas.93.14.7149 [Google Scholar]
  45. Woloszynska-Read, A., James S.R., Link P.A., Yu J., Odunsi K., Karpf, A.R. DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer. Cancer Immun. 2007;7:21. Published 2007 Dec 21. [Google Scholar]
  46. Steele, N., Finn P., Brown R., Plumb, J.A. Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br J Cancer. 2009;100(5):758–763. doi: 10.1038/sj.bjc.6604932 [Google Scholar]
  47. Rao, M., Chinnasamy N., Hong J.A., et al. Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res. 2011;71(12):4192–4204. doi: 10.1158/0008-5472.CAN-10-2442 [Google Scholar]
  48. Yazarlou, F., Mowla S.J., Oskooei V.K., Motevaseli E., Tooli L.F., Afsharpad M., Nekoohesh L., Sanikhani N.S., Ghafouri-Fard S., Modarressi MH Cancer Manag Res. 2018; 10(1):5373–5381. [Google Scholar]
  49. Cui, Z., Chen Y., Hu M., Lin Y., Zhang S., Kong L., Chen Y Clin Chim Acta. 2020 Apr; 503(1):203–209. [Google Scholar]
  50. Kothandan, V.K., Kothandan S., Kim D.H., et al. Crosstalk between Stress Granules, Exosomes, Tumour Antigens, and Immune Cells: Significance for Cancer Immunity. Vaccines (Basel). 2020;8(2):172. Published 2020 Apr 8. doi: 10.3390/vaccines8020172 [Google Scholar]
  51. Wei, X., Chen F., Xin K., et al. Cancer-Testis Antigen Peptide Vaccine for Cancer Immunotherapy: Progress and Prospects. Transl Oncol. 2019;12(5):733–738. doi: 10.1016/j.tranon.2019.02.008 [Google Scholar]
  52. Thomas, R., Al-Khadairi G., Roelands J., Hendrickx W., Dermime S., Bedognetti D., Decock J. NY-ESO-1 based immunotherapy of cancer: current perspectives. Front Immunol. 2018;9:947. [Google Scholar]
  53. Yamaguchi, H., Tanaka F., Ohta M., Inoue H., Mori M. Identification of HLA-A24-restricted CTL epitope from cancer-testis antigen, NY-ESO-1, and induction of a specific antitumor immune response. Clin Cancer Res. 2004;10:890–896. [Google Scholar]
  54. Eikawa, S., Kakimi K., Isobe M., Kuzushima K., Luescher I., Ohue Y., Ikeuchi K., Uenaka A., Nishikawa H., Udono H. Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide. Int J Cancer. 2013;132:345–354. [Google Scholar]

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